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PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.

PLoS genetics - 1 Apr 2011

Narasimhan Sri Devi, Yen Kelvin, Bansal Ankita, Kwon Eun-Soo, Padmanabhan Srivatsan, Tissenbaum Heidi A

Abstract excerpt

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1 receptor tyrosine kinase), AGE-1 (PI 3-kinase), and additional downstream serine/threonine kinases that ultimately phosphorylate and negatively regulate the single FOXO transcription factor homolog DAF-16. Phosphatases help to...

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Animals, Genetically Modified
Caenorhabditis elegans Proteins
Forkhead Transcription Factors
Insulin
Longevity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, IGF Type 1

Receptor, Insulin

Receptors, Transforming Growth Factor beta

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Identifiers

PMID: 21533078
DOI: 10.1371/journal.pgen.1001377
PMCID: PMC3080858

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