Article
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
Genes & development - 1 Jun 1999
Paradis S, Ailion M, Toker A, Thomas J H, Ruvkun G
Abstract excerpt
An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1 and AKT-2 kinases causes a developmental arrest at the dauer stage. A null mutation in the daf-16 Fork head transcription factor alleviates the requirement for signaling through this pathway. We show here that a...
Topics
- 3-Phosphoinositide-Dependent Protein Kinases
- Alanine
- Alleles
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Enzyme Activation
- Gene Expression Regulation, Enzymologic
- Green Fluorescent Proteins
- Helminth Proteins
- Humans
- Luminescent Proteins