Article

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments

2020-05-08

Abstract excerpt

Over a decade of genome-wide association studies (GWAS) have led to the finding of extreme polygenicity of complex traits. The phenomenon that “all genes affect every complex trait” complicates Mendelian Randomization (MR) studies, where natural genetic variations are used as instruments to infer the causal effect of heritable risk factors. We reexamine the assumptions of existing MR methods and show how they need...

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Literature Corpus work: e594f4d0-06a2-5cd9-818a-e223b47a3365
DOI: 10.1101/2020.05.06.077982

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