Article

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

2020-01-28

Abstract excerpt

Mendelian Randomisation (MR), an increasingly popular method that estimates the causal effects of risk factors on complex human traits, has seen several extensions that relax its basic assumptions. However, most of these extensions suffer from two major limitations; their under-exploitation of genome-wide markers, and sensitivity to the presence of a heritable confounder of the exposure-outcome relationship. To ov...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 246e1ee8-c9f5-570e-a133-13d4170306be
DOI: 10.1101/2020.01.27.20018929

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statisticsDOI 10.1101/2020.01.27.20018929Read

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statisticsSemantic proximity Read

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instrumentsSemantic proximity Read

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments.Semantic proximity Read

Distinguishing genetic correlation from causation across 52 diseases and complex traitsSemantic proximity Read

Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data.Semantic proximity Read

Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data.Semantic proximity Read

Causal associations between risk factors and common diseases inferred from GWAS summary data.Semantic proximity Read

Leveraging polygenic risk scores to infer causal directions in genotype-by-environment interactions between complex traits.Semantic proximity Read

Causal associations between risk factors and common diseases inferred from GWAS summary dataSemantic proximity Read

METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.Semantic proximity Read

Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomization.Semantic proximity Read

Causal inference for multiple risk factors and diseases from genomics dataSemantic proximity Read