Article

Distinguishing genetic correlation from causation across 52 diseases and complex traits

2017-10-18

Abstract excerpt

Mendelian randomization (MR) is widely used to identify causal relationships among heritable traits, but it can be confounded by genetic correlations reflecting shared etiology. We propose a model in which a latent causal variable mediates the genetic correlation between two traits. Under the latent causal variable (LCV) model, trait 1 is fully genetically causal for trait 2 if it is perfectly genetically correla...

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Literature Corpus work: dc8e8eba-9d75-551e-9829-44551bc2046c
DOI: 10.1101/205435

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