Article

Widespread pleiotropy confounds causal relationships between complex traits and diseases inferred from Mendelian randomization

2017-06-30

Abstract excerpt

A fundamental assumption in inferring causality of an exposure on complex disease using Mendelian randomization (MR) is that the genetic variant used as the instrumental variable cannot have pleiotropic effects. Violation of this ‘no pleiotropy’ assumption can cause severe bias. Emerging evidence have supported a role for pleiotropy amongst disease-associated loci identified from GWA studies. However, the impact a...

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Literature Corpus work: d1fe49e2-8441-54ab-b2f6-2ad4bd273701
DOI: 10.1101/157552

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