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Article

METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.

Briefings in bioinformatics - 3 Jul 2026

Zhang Liye, Yan Ran, Gong Weiming, Zhou Xiang, Liu Lu, Yuan Zhongshang

Abstract excerpt

Accurate identification of causal exposures for multimorbidity can benefit the co-prevention and co-management of multiple-related outcomes. This goal can be conceptually addressed within a multi-outcome Mendelian randomization (MR) framework. However, existing multi-outcome MR methods suffer from restrictions on format and availability of data inputs, fail to account for the potential sample overlap, rely on...

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Algorithms
Genome-Wide Association Study
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

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PMID: 42407119
DOI: 10.1093/bib/bbag364
PMCID: PMC13336660

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