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Article

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments.

PLoS genetics - 1 Jun 2021

Wang Jingshu, Zhao Qingyuan, Bowden Jack, Hemani Gibran, Davey Smith George, Small Dylan S, Zhang Nancy R

Abstract excerpt

Over a decade of genome-wide association studies (GWAS) have led to the finding of extreme polygenicity of complex traits. The phenomenon that "all genes affect every complex trait" complicates Mendelian Randomization (MR) studies, where natural genetic variations are used as instruments to infer the causal effect of heritable risk factors. We reexamine the assumptions of existing MR methods and show how they...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 34157017
DOI: 10.1371/journal.pgen.1009575
PMCID: PMC8301661

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