Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

14 Dec 2021

Abstract excerpt

Mendelian Randomisation (MR) is an increasingly popular approach that estimates the causal effect of risk factors on complex human traits. While it has seen several extensions that relax its basic assumptions, most suffer from two major limitations; their under-exploitation of genome-wide markers, and sensitivity to the presence of a heritable confounder of the exposure-outcome relationship. To overcome these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folate and B Vitamins Research
Share to Genetic and phenotypic traits in livestock
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34907193
DOI: 10.1038/s41467-021-26970-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statisticsPMID 34907193Read ↗

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statisticsSemantic proximity Read ↗

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments.Semantic proximity Read ↗

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instrumentsSemantic proximity Read ↗

Distinguishing genetic correlation from causation across 52 diseases and complex traitsSemantic proximity Read ↗

Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data.Semantic proximity Read ↗

Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomization.Semantic proximity Read ↗

Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data.Semantic proximity Read ↗

Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomizationSemantic proximity Read ↗

METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.Semantic proximity Read ↗

Causal inference for multiple risk factors and diseases from genomics dataSemantic proximity Read ↗

Leveraging polygenic risk scores to infer causal directions in genotype-by-environment interactions between complex traits.Semantic proximity Read ↗

Causal associations between risk factors and common diseases inferred from GWAS summary data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.