Article

Pan-cancer Analysis of Homologous Recombination Deficiency in Cell Lines

2024-05-20

Abstract excerpt

<h4>ABSTRACT</h4> Homologous Recombination Deficiency (HRD) drives genomic instability in multiple cancer types and renders tumors vulnerable to certain DNA damaging agents such as PARP inhibitors. Thus, HRD is emerging as an attractive biomarker in oncology. A variety of in silico methods are available for predicting HRD; however, few of these methods have been applied to cell lines in a comprehensive manner. He...

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Literature Corpus work: e57e7546-5f9e-5a71-a007-634b731e553e
DOI: 10.1101/2024.05.16.594524

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