Article
Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines
1 Nov 2024
Abstract excerpt
ABSTRACT: Homologous recombination deficiency (HRD) drives genomic instability in multiple cancer types and renders tumors vulnerable to certain DNA-damaging agents such as PARP inhibitors. Thus, HRD is emerging as an attractive biomarker in oncology. A variety of in silico methods are available for predicting HRD; however, few of these methods have been applied to cell lines in a comprehensive manner. Here, we...