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Article

Recent Advances in Genomic Approaches for the Detection of Homologous Recombination Deficiency.

Cancer research and treatment - 1 Oct 2024

Kim Yoo-Na, Gulhan Doga C, Jin Hu, Glodzik Dominik, Park Peter J

Abstract excerpt

Accurate detection of homologous recombination deficiency (HRD) in cancer patients is paramount in clinical applications, as HRD confers sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. With the advances in genome sequencing technology, mutational profiling on a genome-wide scale has become readily accessible, and our knowledge of the genomic consequences of HRD has been greatly expanded and refined....

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Identifiers

PMID: 39026430
DOI: 10.4143/crt.2024.154
PMCID: PMC11491256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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