Article

Validation of Genomic and Transcriptomic Models of Homologous Recombination Deficiency in a Real-World Pan-Cancer Cohort

2021-12-21

Abstract excerpt

<h4>Background</h4> With the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumor types. Following the strong clinical evidence for the utility of DNA-sequencing-based HRD testing in ovarian cancer, and growing evidence in breast cancer, we present analytical validati...

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Literature Corpus work: 6db12eea-3a10-5a3a-bfcb-d3dab38811c3
DOI: 10.1101/2021.12.20.21267985

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