Article

Pan-cancer landscape of homologous recombination deficiency

2020-01-14

Abstract excerpt

Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we developed a genome-wide mutational scar-based pan-cancer C lassifier of HO mologous R ecombination D eficiency (CHORD) that can discriminate BRCA1- and BRCA2-subtypes. Analysis of a metastatic (n=3,504) and primary (n=1,854) pan-cancer cohort revealed HRD was most frequen...

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Literature Corpus work: ee49ec26-a253-52b1-aab5-6068bc15b979
DOI: 10.1101/2020.01.13.905026

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