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Article

Pan-cancer landscape of homologous recombination deficiency.

Nature communications - 4 Nov 2020

Nguyen Luan, W M Martens John, Van Hoeck Arne, Cuppen Edwin

Abstract excerpt

Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD) that can discriminate BRCA1- and BRCA2-subtypes. Analysis of a metastatic (n = 3,504) and primary (n = 1,854) pan-cancer cohort reveals that HRD is most frequent...

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Identifiers

PMID: 33149131
DOI: 10.1038/s41467-020-19406-4
PMCID: PMC7643118

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