Article

The utility of homologous recombination deficiency biomarkers across cancer types

2021-02-20

Abstract excerpt

<h4>Background</h4> Genomic alterations in BRCA1/2 and genomic scar signatures are associated with homologous recombination DNA repair deficiency (HRD) and serve as therapeutic biomarkers for platinum and PARP inhibitors in breast and ovarian cancers. However, the clinical significance of these biomarkers in other homologous recombination repair-related genes or other cancer types is not fully understood. <h4>Resu...

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Literature Corpus work: 389ccddb-703f-5ae8-ac24-80984167b8f6
DOI: 10.1101/2021.02.18.21251882

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