Article

Homologous recombination deficiency in cell line libraries does not correlate with in vitro sensitivity to platinum agents or PARP inhibitors

2023-07-07

Abstract excerpt

Although preclinical studies for drug discovery and biomarker development are extensively conducted using large publicly available cancer cell line databases, there have been no reports to date that clarify the association between homologous recombination repair deficiency (HRD) and drug sensitivity using these data. We comprehensively analyzed the molecular profiles and drug response screening data from the Cance...

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Literature Corpus work: 24760c14-ac36-5fc4-84df-8608e819217d
DOI: 10.1101/2023.07.06.547853

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