Article

Whole Genome Landscape Analysis of Homologous Recombination Deficiency in a Pan-Cancer Cohort

2024-06-30

Abstract excerpt

<h4>Purpose</h4> Homologous recombination deficiency (HRD) impacts cancer treatment strategies, particularly the effectiveness of PARP inhibitors. However, the variability different HRD assays has hampered the selection of oncology patients who may benefit from these therapies. Our study aims to assess the whole genome landscape to better define HRD in a pan-cancer cohort and to contribute to harmonization of HRD...

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Literature Corpus work: ecb92d71-681f-5643-9ced-8e29b191f49f
DOI: 10.1101/2024.06.28.24309592

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