Back to search

Article

Whole Genome Analysis Identifies Homologous Recombination Deficiency in Cancers with BRCA1/2 Wild-Type and BRCA1/2 Structural Variants

2024-11-29

Abstract excerpt

<title>Abstract</title> <p> Purpose Homologous recombination deficiency (HRD) impacts cancer treatment strategies, particularly effective utilization of PARP inhibitors. However, the variability of different HRD assays has hampered the selection of oncology patients who may benefit from these therapies. Our study aims to use the whole genome landscape to better define HRD in a pan-cancer cohort. Methods We emp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f4d42fcf-82c3-568e-84b2-e6c7b53005ef
DOI
10.21203/rs.3.rs-4978638/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Whole Genome Analysis Identifies Homologous Recombination Deficiency in Cancers with BRCA1/2 Wild-Type and BRCA1/2 Structural VariantsDOI 10.21203/rs.3.rs-4978638/v1
Whole Genome Landscape Analysis of Homologous Recombination Deficiency in a Pan-Cancer CohortSemantic proximity
Biomarkers for Homologous Recombination Deficiency in CancerSemantic proximity
The utility of homologous recombination deficiency biomarkers across cancer typesSemantic proximity
Utility of Homologous Recombination Deficiency Biomarkers Across Cancer TypesSemantic proximity
Pan-cancer landscape of homologous recombination deficiencySemantic proximity
Pan-cancer landscape of homologous recombination deficiency.Semantic proximity
Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD)Semantic proximity
Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell LinesSemantic proximity
The Homologous Recombination Deficiency Scar in Advanced Cancer: Agnostic Targeting of Damaged DNA RepairSemantic proximity
Prediction of homologous recombination deficiency identifies colorectal tumors sensitive to PARP inhibitionSemantic proximity
Recent Advances in Genomic Approaches for the Detection of Homologous Recombination Deficiency.Semantic proximity
Genomic Determinants of Homologous Recombination Deficiency across Human CancersSemantic proximity
Select a neighboring publication to make it the new centre.