Article

Mitochondrial DNA mosaicism in human normal somatic cells

2023-11-21

Abstract excerpt

<title>Abstract</title> <p>Genomic alterations accumulate in the somatic cells throughout an individual’s lifetime<sup>1-5</sup>. Recent sequencing studies have documented widespread mutations in the nuclear genome and the frequent clonal competition of normal cells carrying mutations<sup>6-11</sup>. However, the landscape of mitochondrial DNA (mtDNA) heteroplasmy in normal human tissues is poorly understood. In...

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Literature Corpus work: 8f0a3826-c9c1-53cc-8855-4f8c64f209ff
DOI: 10.21203/rs.3.rs-3602675/v1

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