Article

A mutational gradient drives somatic mutation accumulation in mitochondrial DNA and influences germline polymorphisms and genome composition

2021-06-18

Abstract excerpt

<h4>Background</h4> Mutations in the mitochondrial genome (mtDNA) can cause devastating maternally inherited diseases, while the accumulation of somatic mtDNA mutations is linked to common diseases of aging. Although mtDNA mutations impact human health, the process(es) that give rise to these mutations are unclear and are under considerable debate. We analyzed the distribution of naturally occurring somatic mutat...

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Literature Corpus work: 9bb36fed-b101-5133-bfbc-6797a2d299f6
DOI: 10.1101/2021.06.18.448725

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