Article

Large-scale single-cell mapping of concealed mitochondrial ageing

2026-07-20

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations have been linked to ageing. We find that the mtDNA mutations detected in routine bulk sequencing are greatly outnumbered by a class of concealed mutations that, despite being in a proliferative tissue, show little negative selection. Combining new scATAC-seq experiments with existing scRNA-seq, we map mtDNA mutations across 2.7 million cells from 311 individuals, covering 11 pro...

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Literature Corpus work: 1d227f0e-4753-58b0-b171-6cc764d234a7
DOI: 10.64898/2026.07.14.738425

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