Article
High-frequency and functional mitochondrial DNA mutations at the single-cell level.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jan 2023
Guo Xiaoxian, Xu Weilin, Zhang Weiping, Pan Cuiping, Thalacker-Mercer Anna E, Zheng Hongxiang, Gu Zhenglong
Abstract excerpt
Decline in mitochondrial function underlies aging and age-related diseases, but the role of mitochondrial DNA (mtDNA) mutations in these processes remains elusive. To investigate patterns of mtDNA mutations, it is particularly important to quantify mtDNA mutations and their associated pathogenic effects at the single-cell level. However, existing single-cell mtDNA sequencing approaches remain inefficient due to...
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