Article

Chromatin accessibility changes induced by the microbial metabolite butyrate reveal possible mechanisms of anti-cancer effects

2021-03-31

Abstract excerpt

<h4>Summary</h4> Butyrate is a four-carbon fatty acid produced in large quantities by bacteria found in the human gut. It is the major source of colonic epithelial cell energy, can bind to and agonize short-chain fatty acid G-protein coupled receptors and functions as a histone deacetylase (HDAC) inhibitor. Anti-cancer effects of butyrate are attributed to a global increase in histone acetylation in colon cancer...

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Literature Corpus work: e54cd879-83dc-5826-815d-e186b34616a9
DOI: 10.1101/2021.03.30.437582

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