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Article

Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cells

9 Apr 2014

Abstract excerpt

BACKGROUND: We have determined that butyrate, which is derived from the fermentation of dietary fiber in the colonic lumen, hyperactivates Wnt activity in colorectal (CRC) cells, and that this upregulation of Wnt signaling is causatively related to the induction of apoptosis. To better understand the genetic program regulated by butyrate-mediated Wnt hyperactivation, we performed total human genome microarray...

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PMID: 24716727
DOI: 10.1186/1756-0500-7-226

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