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Article

The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

27 Feb 2012

Abstract excerpt

Butyrate is a short chain fatty acid derived from the microbial fermentation of dietary fibers in the colon. In the last decade, multiple beneficial effects of butyrate at intestinal and extraintestinal level have been demonstrated. The mechanisms of action of butyrate are different and many of these involve an epigenetic regulation of gene expression through the inhibition of histone deacetylase. There is a...

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PMID: 22414433
DOI: 10.1186/1868-7083-4-4

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