Article

Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa

2026-01-08

Abstract excerpt

Microbial-derived short-chain fatty acids regulate a variety of pathways in the healthy colonic mucosa. In particular, butyrate serves as the primary energy source for colonocytes and regulates gene transcription by stabilizing the transcription factor hypoxia-inducible-factors (HIF) and functioning as a histone deacetylase (HDAC) inhibitor. A limitation of butyrate as a therapeutic is its rapid metabolism in diff...

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Literature Corpus work: 37937625-512b-5f19-aba1-66ff65592ee9
DOI: 10.64898/2026.01.07.697087

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