Article

Butyrate modulates the epigenetic landscape of human natural killer cells and affects their regulatory function

2024-09-06

Abstract excerpt

<title>Abstract</title> <p>Gut bacteria-derived metabolites, such as butyrate (BUT), shape the function of T cells through inhibition of histone deacetylases (HDAC). Natural killer (NK) cells are innate lymphocytes with important effector and regulatory functions; little is known on the effect of BUT on NK cells. Here we aimed at evaluating whether BUT affects the epigenetic landscape of human NK cells. We found...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f1eac94-e8bd-5803-81d3-d5727b53edba
DOI: 10.21203/rs.3.rs-4870357/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Butyrate modulates the epigenetic landscape of human natural killer cells and affects their regulatory functionDOI 10.21203/rs.3.rs-4870357/v1Read

T-BET and EOMES sustain mature human NK cell identity and antitumor functionSemantic proximity Read

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genesSemantic proximity Read

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulationSemantic proximity Read

Butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulationSemantic proximity Read

Chromatin accessibility changes induced by the microbial metabolite butyrate reveal possible mechanisms of anti-cancer effectsSemantic proximity Read

A Temporal Transcriptional Map of Human Natural Killer Cell DifferentiationSemantic proximity Read

The epigenetic effects of butyrate: potential therapeutic implications for clinical practiceSemantic proximity Read

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells.Semantic proximity Read

Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulationSemantic proximity Read

Adaptation of Natural Killer Cells to Hypoxia: A Review of the Transcriptional, Translational, and Metabolic ProcessesSemantic proximity Read

Tissue-resident Eomes(hi) T-bet(lo) CD56(bright) NK cells with reduced proinflammatory potential are enriched in the adult human liver.Semantic proximity Read

A Bacterial Bile Acid Metabolite Modulates T <sub>reg</sub> Activity through the Nuclear Hormone Receptor NR4A1Semantic proximity Read