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Article

The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation.

The Journal of nutrition - 1 May 2002

Hinnebusch Brian F, Meng Shufen, Wu James T, Archer Sonia Y, Hodin Richard A

Abstract excerpt

The short-chain fatty acid (SCFA) butyrate is produced via anaerobic bacterial fermentation within the colon and is thought to be protective in regard to colon carcinogenesis. Although butyrate (C4) is considered the most potent of the SCFA, a variety of other SCFA also exist in the colonic lumen. Butyrate is thought to exert its cellular effects through the induction of histone hyperacetylation. We sought to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11983830
DOI: 10.1093/jn/132.5.1012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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