Article
An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression.
Genome biology - 23 Jan 2018
Qin Yufeng, Roberts John D, Grimm Sara A, Lih Fred B, Deterding Leesa J, Li Ruifang, Chrysovergis Kaliopi, Wade Paul A
Abstract excerpt
BACKGROUND: The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin features and, ultimately, gene expression. How the host mediates epigenomic responses to gut microbiota is an emerging area of interest. Here, we profile the gut...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.