Article

Myeloid Lineage Enhancers Drive Oncogene Synergy in CEBPA/CSF3R Mutant Acute Myeloid Leukemia

2019-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional classes. Here, we demonstrate that activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function mutations in the transcription factor CEBPA to promote acute leukemia development. This finding of mutation-synergy is broadly applicable other muta...

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Literature Corpus work: e54a1ac9-b6dc-5ce0-9483-50b8f346dafb
DOI: 10.1101/639617

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