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Article

Complexity of CEBPA dysregulation in human acute myeloid leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2009

Pabst Thomas, Mueller Beatrice U

Abstract excerpt

The transcription factor CCAAT enhancer binding protein alpha (CEBPA) is crucial for normal development of granulocytes. Various mechanisms have been identified how CEBPA function is dysregulated in patients with acute myeloid leukemia (AML). In particular, dominant-negative mutations located either at the N- or the C terminus of the CEBPA gene are observed in roughly 10% of AML patients, either in the...

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Source

Identifiers

PMID: 19706798
DOI: 10.1158/1078-0432.CCR-08-2941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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