Article

<i>TET2</i> lesions enhance the aggressiveness of <i>CEBPA-</i> mutant AML by rebalancing <i>GATA2</i> expression

2023-03-29

Abstract excerpt

<h4>ABSTRACT</h4> The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated; CEBPA DM ) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations ( CEBPA NT ), promoting expression of the leukemia-associated p30 isoform, and amorphic C-terminal mutations. The most frequently co-mutated genes in CEBPA DM AML are GATA2 and TET2 , however the...

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Literature Corpus work: a2c04c15-d486-512f-a396-95013ceff88b
DOI: 10.1101/2023.03.28.534511

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