Article
Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.
Blood - 26 Oct 2017
Dovey Oliver M, Cooper Jonathan L, Mupo Annalisa, Grove Carolyn S, Lynn Claire, Conte Nathalie, Andrews Robert M, Pacharne Suruchi, Tzelepis Konstantinos, Vijayabaskar M S, Green Paul, Rad Roland, Arends Mark, Wright Penny, Yusa Kosuke, Bradley Allan, Varela Ignacio, Vassiliou George S
Abstract excerpt
NPM1 mutations define the commonest subgroup of acute myeloid leukemia (AML) and frequently co-occur with FLT3 internal tandem duplications (ITD) or, less commonly, NRAS or KRAS mutations. Co-occurrence of mutant NPM1 with FLT3-ITD carries a significantly worse prognosis than NPM1-RAS combinations. To understand the molecular basis of these observations, we compare the effects of the 2 combinations on...
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