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Article

CEBPA-bZip mutations are associated with favorable prognosis in de novo AML: a report from the Children's Oncology Group.

Blood - 30 Sept 2021

Tarlock Katherine, Lamble Adam J, Wang Yi-Cheng, Gerbing Robert B, Ries Rhonda E, Loken Michael R, Brodersen Lisa Eidenschink, Pardo Laura, Leonti Amanda, Smith Jenny L, Hylkema Tiffany A, Woods William G, Cooper Todd M, Kolb E Anders, Gamis Alan S, Aplenc Richard, Alonzo Todd A, Meshinchi Soheil

Abstract excerpt

Biallelic CEBPA mutations are associated with favorable outcomes in acute myeloid leukemia (AML). We evaluated the clinical and biologic implications of CEBPA-basic leucine zipper (CEBPA-bZip) mutations in children and young adults with newly diagnosed AML. CEBPA-bZip mutation status was determined in 2958 patients with AML enrolled on Children's Oncology Group trials (NCT00003790, NCT0007174, NCT00372593,...

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Share to Basic-Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33951732
DOI: 10.1182/blood.2020009652
PMCID: PMC8570058

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