Article
CSF3R Mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia.
Cancer - 1 Aug 2018
Zhang Yang, Wang Fang, Chen Xue, Zhang Yu, Wang Mingyu, Liu Hong, Cao Panxiang, Ma Xiaoli, Wang Tong, Zhang Jianping, Zhang Xian, Lu Peihua, Liu Hongxing
Abstract excerpt
BACKGROUND: Mutations in the colony-stimulating factor 3 receptor (CSF3R) gene occur frequently in chronic neutrophilic leukemia and are rare in de novo acute leukemia. The objective of this study was to assess the incidence of CSF3R mutations in acute leukemia and their association with other genetic abnormalities. METHODS: Amplicon-targeted, next-generation sequencing of 58 genes was performed retrospectively...
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