Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia.

doi:10.1038/s41467-019-13364-2

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Article

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia.

Nature communications - 29 Nov 2019

Braun Theodore P, Okhovat Mariam, Coblentz Cody, Carratt Sarah A, Foley Amy, Schonrock Zachary, Curtiss Brittany M, Nevonen Kimberly, Davis Brett, Garcia Brianna, LaTocha Dorian, Weeder Benjamin R, Grzadkowski Michal R, Estabrook Joey C, Manning Hannah G, Watanabe-Smith Kevin, Jeng Sophia, Smith Jenny L, Leonti Amanda R, Ries Rhonda E, McWeeney Shannon, Di Genua Cristina, Drissen Roy, Nerlov Claus, Meshinchi Soheil, Carbone Lucia, Druker Brian J, Maxson Julia E

Abstract excerpt

Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional classes. Here, we demonstrate that activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function mutations in the transcription factor CEBPA to promote acute leukemia development. The interaction between these distinct classes of mutations occurs at the level of...

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Identifiers

PMID: 31784538
DOI: 10.1038/s41467-019-13364-2
PMCID: PMC6884457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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