Article

Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies

2024-05-31

Abstract excerpt

Targeted recruitment of E3 ubiquitin ligases to degrade traditionally undruggable proteins is a disruptive paradigm for developing new therapeutics. Two salient limitations are that <2% of the ~600 E3 ligases in the human genome have been exploited to produce proteolysis targeting chimeras (PROTACs), and the efficacy of the approach has not been demonstrated for a vital class of complex multi-subunit membrane prot...

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Literature Corpus work: e53bcb29-3533-5e63-a42f-30f251bff6a4
DOI: 10.1101/2024.05.28.596281

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