Article

Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox

2022-11-01

Abstract excerpt

<h4>ABSTRACT</h4> In recent years, targeted protein degradation (TPD) of plasma membrane proteins by hijacking the ubiquitin proteasome system (UPS) or the lysosomal pathway have emerged as novel therapeutic avenues in drug development to address and inhibit canonically difficult targets. While TPD strategies have been successful to target cell surface receptors, these approaches are limited by the availability o...

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Literature Corpus work: bd604483-56d8-5175-9100-1c4c74683b1e
DOI: 10.1101/2022.10.31.514624

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