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Article

Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting.

Journal of neurophysiology - 1 Aug 2016

Vélez Patricio, Schwartz Austin B, Iyer Subashini R, Warrington Anthony, Fadool Debra Ann

Abstract excerpt

Voltage-dependent potassium channels (Kv) go beyond the stabilization of the resting potential and regulate biochemical pathways, regulate intracellular signaling, and detect energy homeostasis. Because targeted deletion and pharmacological block of the Kv1.3 channel protein produce marked changes in metabolism, resistance to diet-induced obesity, and changes in olfactory structure and function, this...

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Identifiers

PMID: 27146988
DOI: 10.1152/jn.00874.2015
PMCID: PMC4982906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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