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Integrated proteomic screening reveals design principles of CRBN molecular glue degraders

2026-03-10

Abstract excerpt

Cereblon (CRBN)-based molecular glue degraders (MGDs) induce the degradation of diverse disease-relevant proteins, underscoring their broad therapeutic potential. Here we systematically expand the CRBN neosubstrate landscape using a target-agnostic discovery approach. By integrating deep proteomic and ubiquitinomic profiling of a 960-compound library, we identify compound-induced ubiquitination and depletion of ov...

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Identifiers and source

Literature Corpus work
3e75e7a6-377b-560a-b6aa-bbc31b8c4030
DOI
10.64898/2026.03.08.710269
Open publication

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Integrated proteomic screening reveals design principles of CRBN molecular glue degradersDOI 10.64898/2026.03.08.710269
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