Article
Design principles of a membrane-spanning ubiquitin ligase.
Molecular cell - 4 Jun 2026
Williams Carys, Nocka Laura M, Hedger George, Parashara Pragya, Pardon Els, Latorraca Naomi R, Pusapati Ganesh V, Sarkar Parijat, Lartey Dorothy, Gao Lei, Milenkovic Ljiljana, Chalk Rod, Steyaert Jan, Marqusee Susan, Carrique Loïc, Bazan J Fernando, Rouse Sarah L, Kong Jennifer H, Siebold Christian, Rohatgi Rajat
Abstract excerpt
Receptor-type E3 ubiquitin ligases enable extracellular signals to control ubiquitylation in the cytoplasm, playing widespread roles in development, metabolism, and immunity. Using cryoelectron microscopy, integrated with biophysical and functional studies, we visualized a human E3 complex composed of two transmembrane proteins, MEGF8 and MOSMO, and the intracellular RING-family protein MGRN1. This...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.