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“Design principles of a membrane-spanning ubiquitin ligase”

2025-09-16

Abstract excerpt

<h4>Summary</h4> Receptor-type E3 ubiquitin ligases are membrane-spanning assemblies that enable extracellular signals to directly control ubiquitylation in the cytoplasm. Despite playing widespread roles in tissue patterning and homeostasis, metabolism, and immunity, their structures and mechanisms remain poorly understood. Using cryo-electron microscopy, integrated with biophysical and functional studies, we vi...

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Literature Corpus work
2eecf451-20c9-530c-af16-1736c1de849e
DOI
10.1101/2025.09.11.675358
Open publication

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“Design principles of a membrane-spanning ubiquitin ligase”DOI 10.1101/2025.09.11.675358
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