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Article

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

2024-01-20

Abstract excerpt

The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural investigation of CRBN has been limited by current constructs that either require co-expression with the adaptor DDB1 or inadequately represent full-length protein, with high-resol...

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Literature Corpus work
8c8db633-c1a0-5d4a-97cf-8a34a68fb235
DOI
10.1101/2024.01.17.575503
Open publication

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Design of a Cereblon construct for crystallographic and biophysical studies of protein degradersDOI 10.1101/2024.01.17.575503
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