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G-Quadruplex Structures Are Key Modulators of Somatic Structural Variants in Cancers

15 Feb 2023

Abstract excerpt

G-quadruplexes (G4) are noncanonical secondary genome structures. Aberrant formation of G4s can impair genome integrity. Investigation of the relationship between G4s and somatic structural variants (SV) in cancers could provide a better understanding of the role of G4 formation in cancer development and progression. In this study, we combined bioinformatic approaches and multiomics data to investigate the...

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PMID: 36791413
DOI: 10.1158/0008-5472.can-22-3089

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