Article
Mutational signatures and mutable motifs in cancer genomes.
Briefings in bioinformatics - 27 Nov 2018
Rogozin Igor B, Pavlov Youri I, Goncearenco Alexander, De Subhajyoti, Lada Artem G, Poliakov Eugenia, Panchenko Anna R, Cooper David N
Abstract excerpt
Cancer is a genetic disorder, meaning that a plethora of different mutations, whether somatic or germ line, underlie the etiology of the 'Emperor of Maladies'. Point mutations, chromosomal rearrangements and copy number changes, whether they have occurred spontaneously in predisposed individuals or have been induced by intrinsic or extrinsic (environmental) mutagens, lead to the activation of oncogenes and...
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