Article

Bulk and Single-nucleus Transcriptomics Highlight Intra-telencephalic and Somatostatin Neurons in Alzheimer’s Disease

2022-01-13

Abstract excerpt

<h4>Background</h4> Cortical neuron loss is a pathological hallmark of late-onset Alzheimer’s disease (AD). However, it remains unclear which neuronal subtypes are most vulnerable to degeneration and contribute most to cognitive decline. <h4>Methods</h4> We analyzed postmortem bulk brain RNA-sequencing (RNAseq) data collected from three studies of aging and AD comprising six neocortical regions (704 individuals;...

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Literature Corpus work: e41ad974-e590-544f-8328-26b49dbc9dfe
DOI: 10.1101/2022.01.12.476076

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