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Article

Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores.

Neurobiology of aging - 1 Nov 2025

O'Neill Nicholas, Kurniansyah Nuzulul, Zhu Congcong, Olayinka Oluwatosin A, Mayeux Richard, Haines Jonathan L, Pericak-Vance Margaret A, Wang Li-San, Schellenberg Gerard D, Farrer Lindsay A, Zhang Xiaoling

Abstract excerpt

Alzheimer disease (AD) polygenic risk scores (ADPRS) built from cell-type (ct) specific genetic variants can be used to infer cell-type contributions to AD. We derived two ct-ADPRSs using variants near single-nuclei RNA-seq (snRNA) derived cell-type specific genes or on single-nuclei ATAC-seq (snATAC) derived cell-type specific accessible chromatin regions. We generated a multi-omic ct-ADPRS for eight neuron...

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Identifiers

PMID: 40706314
DOI: 10.1016/j.neurobiolaging.2025.07.009
PMCID: PMC13077728

Genes

ADPRS
NPY
SST

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