Article

CYP1B1 converts procarcinogens into genotoxins in <i>Saccharomyces cerevisiae</i>

2021-07-22

Abstract excerpt

<h4>ABSTRACT</h4> CYP1B1 activates many chemical carcinogens into potent genotoxins, and allelic variants are risk factors in lung, breast, and prostate cancer. However, genetic instability phenotypes incurred by CYP1B1-activated metabolites have been investigated for only few compounds. In this study, we expressed human CYP1B1 in yeast strains that measure DNA damage-associated toxicity and frequencies of chromo...

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Literature Corpus work: e85e6e50-540f-516e-bc95-69c666f520e7
DOI: 10.1101/2021.07.22.453414

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