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High-Throughput Screening of the <i>Saccharomyces cerevisiae</i> Genome for 2-Amino-3-Methylimidazo [4,5- <i>f</i> ] Quinoline Resistance Identifies Colon Cancer-Associated Genes

2022-10-27

Abstract excerpt

<h4>ABSTRACT</h4> Heterocyclic aromatic amines (HAAs) are potent carcinogenic agents found in charred meats and cigarette smoke. However, few eukaryotic resistance genes have been identified. We used Saccharomyces cerevisiae (budding yeast) to identify genes that confer resistance to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). CYP1A2 and NAT2 activate IQ to become a mutagenic nitrenium compound. We introduced...

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Literature Corpus work
3b1a838b-4462-5e16-b9a1-ae0e79ac2215
DOI
10.1101/2022.10.26.513854
Open publication

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High-Throughput Screening of the <i>Saccharomyces cerevisiae</i> Genome for 2-Amino-3-Methylimidazo [4,5- <i>f</i> ] Quinoline Resistance Identifies Colon Cancer-Associated GenesDOI 10.1101/2022.10.26.513854
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